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LOIS-3D

Laser Optoacoustic Imaging System provides quantitative optoacoustic tomography, qOAT, of the live mouse body and brain

Tomowave's LOIS-3D is a cutting-edge imaging system that utilizes laser optoacoustic and ultrasonic technology to generate high-resolution, three-dimensional images of biological tissues. Designed for both preclinical research and translational studies, it provides detailed insights into tissue composition, function, and pathology with exceptional depth and contrast.

Precision Imaging

Revolutionizing Healthcare

TomoWave develops proprietary optoacoustic tomography and laser ultrasound systems for combined functional/molecular and anatomical imaging with applications in detection of cancer and image-guided interventions

LOIS-3D
Maestro
Symphony

LOIS3D: TomoWave Research Imaging System

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“TomoWave 3D optoacoustic imaging system has unique advantages in in vivo imaging of small animals due to its high resolution and sensitivity. Combined with the small molecule photoacoustic probes developed by our research group, we have successfully achieved real-time imaging and dynamic distribution of brain signaling molecules.”
                                                                                                               Zhiyong Jiang, PhD, Professor, Nanjing University, PRC.

LOIS-3D OptoAcoustic Video and Images
of a mouse body and brain

3D OAT Video Image
of mouse body organs

3D OAT Video Image
of mouse brain

2D cross-sectional
optoacoustic images

LOIS-3D

Laser Optoacoustic Imaging System provides quantitative optoacoustic tomography, qOAT, of the live mouse body and brain

The LOIS-3D (Laser Optoacoustic Imaging System) by TomoWave Laboratories is a state-of-the-art imaging platform designed for high-resolution, non-invasive, three-dimensional visualization of small animals, particularly mice, in preclinical research. By integrating light and sound, LOIS-3D delivers quantitative optoacoustic tomography (qOAT), providing detailed anatomical, molecular, and functional insights into live biological tissues.

Full-View 3D Imaging

Broad Spectral Range

High Sensitivity

Rapid Temporal Resolution

Multimodal Imaging Capabilities

Product: Lois-3D Videos

Anatomical-qOAT, Mouse body

Functional qOAT, mouse [tHb]

Molecular qOAT, mouse [ICG]

Specifications of LOIS-3D system imaging principle: Full View 3D quantitative OptoAacoustic Tomography

120 deg arc array of ultra-wideband 0.1 to 8 MHz transducers,
50000 virtual transducers on 70 mm diameter spherical surface = rigoracquisitionous reconstruction
Minimal Time of Image acquisition: 36 sec min time of image + 48 sec image reconstruction

Full-View 3D Spherical
Imaging Module

LOIS-3D qOAT
Imaging System

Fly through the body

LOIS-3D: Functional OptoAcoustic Imaging
1064nm / 757nm - arterial/venous systems

Arteries @ 1064nm

Veins @ 757nm

Mouse Brain SO2
Functional image @ 757/1064nm

Frequently Asked
Questions

The LOIS-3D (Laser Optoacoustic Imaging System) by TomoWave is a cutting-edge tool designed to provide high-resolution, non-invasive, 3D imaging of small animals for preclinical research. Whether you're a researcher exploring its capabilities for the first time or an experienced user seeking technical specifics, this FAQ addresses common questions about LOIS-3D’s features, applications, and how it supports a wide range of biomedical investigations.

What is the LOIS-3D system, and how does it function?

The LOIS-3D (Laser Optoacoustic Imaging System) is an advanced imaging platform designed for high-resolution, non-invasive, three-dimensional visualization of small animals, particularly mice, in preclinical research. It employs optoacoustic tomography (OAT), a technique that combines the high contrast of optical imaging with the spatial resolution of ultrasound. By delivering nanosecond laser pulses into biological tissues, the system induces thermoacoustic waves, which are then detected by ultrasonic transducers to reconstruct detailed 3D images of internal structures.

What are the key features and capabilities of LOIS-3D?

    • Full-View 3D Imaging: Utilizes a 360° rotational scanning mechanism with a concave arc-shaped transducer array to reconstruct volumetric images with isotropic spatial resolution of approximately 150 microns. Amerigo Scientific

    • Broad Spectral Range: Employs tunable laser wavelengths from 660 nm to 2300 nm, enabling deep tissue imaging and the detection of various chromophores and contrast agents.

    • High Sensitivity: Capable of detecting low concentrations (~1 picomolar) of absorbing nanoparticles, such as gold and silver, facilitating studies in nanomedicine and targeted drug delivery.

    • Rapid Temporal Resolution: Advanced versions offer temporal resolution of 5 seconds per 3D volumetric image, allowing dynamic monitoring of physiological processes.

    • Multimodal Imaging Capabilities:

      • Anatomical Imaging: Visualizes internal structures like organs, vasculature, spine, bones, and skin with high contrast and resolution.

      • Functional Imaging: Maps oxygen saturation and total hemoglobin content using multi-wavelength spectroscopy, critical for assessing tissue oxygenation and blood volume.

      • Molecular Imaging: Tracks the biodistribution of optical contrast agents over time, aiding in pharmacokinetic studies and drug development.

What are the primary applications of LOIS-3D in biomedical research?

LOIS-3D is instrumental in various research domains, including:

  • Cancer Biology and Oncology: Enables visualization of tumor vasculature and monitoring of tumor progression.

  • Drug Development: Assists in evaluating the efficacy and distribution of therapeutic agents.

  • Bio-Nanotechnology: Facilitates studies on nanoparticle behavior and targeting within biological systems.

  • Developmental Biology: Supports research on embryonic development and organogenesis.

  • Neurophysiology: Allows for the examination of cerebral blood flow and brain function in small animal models.

How can researchers acquire or learn more about the LOIS-3D system?

Researchers interested in the LOIS-3D system can visit the official TomoWave Laboratories website at www.tomowave.com. For direct inquiries, they can contact TomoWave via email at general@tomowave.com or by phone at +1-713-270-5393.

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Kim Tillinghast began her career in the banking industry in 1985. She graduated with a degree in Finance from West Texas State University in 1990 and has continued her education by earning her Series 24 General Securities Principal Exam and Certified Plan Fiduciary Advisor (CPFA™). Shortly thereafter she started her brokerage career at a traditional wirehouse in downtown Los Angeles, California in 1991. After relocating to Orange County, Kim became an independent financial advisor in May of 1993. She brings over 37 years in the banking and finance industry with experience ranging from designing, developing, employing and maintaining complex investment strategies, Pension Plans, Employee Stock Option Plans, Corporate Finance, Estate Planning and Transition. Outside of her career, she served as Co-Chair of the Dallas County Susan G. Komen Race for the Cure 2013 and 2014 and currently serves on the Board of the Tillinghast Society, Inc. With a deep love for animals, she continues to volunteer for multiple emergency animal response teams including Red Rover, HSUS, UAN, ASPCA and volunteers weekly at the Irving Animal Shelter. Kim also loves worldwide adventure travel and has many amazing experiences visiting almost half of the world’s countries and all seven continents, twice.

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